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GW-501516 (Cardarine) 品质好货 直发国外
物品单位 价格 品牌
千克 200 天华
  • 产地:中国
  • cas:317318-70-0
  • 发布日期: 2019-12-11
  • 更新日期: 2020-02-21
产品详细说明
主要用途 中间体
产地 中国
EINECS编号 见详情
品牌 天华
货号
生产日期 见详情
别名 2-(4-((2-(4-(三氟甲基)苯基)-5-甲基噻唑-4-基)甲基硫基)-2-甲基苯氧基)乙酸
CAS编号 317318-70-0
保质期 见详情
规格 见详情
分子式 C21H18F3NO3S
产品英文名称

     

抑制剂描述:

产品名称: GW501516

产品别名:GW-501516,GW 501516,GSK516,GSK 516

信号通路:核受体

靶点:PPARδ

CAS:317318-70-0

靶点活性:

PPARδ,EC50:1.1nM


纯度:>98%

外观:White to off-white solid

保存方法:store at -20℃ for one year(Powder);
in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.

描述:GW501516 is a synthetic PPARδ-specific agonist that displays high affinity for PPARδ (Ki=1.1 nM) with > 1000 fold selectivity over PPARα and PPARγ.

溶解性:10 mM in DMSO

体外研究:

GW501516, a potent agonist to PPARδ, modulates glyco-metabolism, fatty acid metabolism and alleviates insulin resistance. GW501516 increases fatty acid oxidation by increasing the levels of hepatic mRNAs associated with fatty acid β-oxidation, such as acyl-CoA oxidase (ACOX), carnitine palmitoyltransferase-1 (CPT-1) and liver fatty acid binding protein (L-FABP). In skeletal muscle cells, treatment with GW501516 has been shown to prevent fatty acid-induced inflammation and insulin resistance in by preventing the phosphorylation of insulin receptor substrate-1 at Ser307 and the inhibition of insulin-stimulated Akt phosphorylation, which is caused by exposure to the saturated fatty acid, palmitate. In human liver cells, treatment with GW501516 has been shown to increase the adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio and decrease the ATP/adenosine diphosphate (ADP) ratio, thus contributing to the prevention of insulin resistance.


体内研究:Treatment with GW501516 alleviates NAFLD by modulating glucose and fatty acid metabolism.


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